1the branch of biology dealing
with the functions and activities of living organisms and their parts
2now Lawrence Berkeley Laboratory,
a National Laboratory under the U.S. Department of Energy; originally founded by
Ernest Lawrence as the UC Radiation Laboratory in 1936
3a laboratory set up at the UC
Radiation Laboratory in Berkeley during the 1930s specifically to conduct
experiments in medical physics. For an inside view of Donner Laboratory's role,
programs, personalities, and day-to-day operations, see DOE/EH-0479, Human Radiation Studies:
Remembering the Early Years; Oral History of Donner Lab Administrator Baird G.
Whaley (September 1995).
4Brookhaven National Laboratory
(BNL) is a multiprogram research laboratory owned by the Department of Energy
and located on 5,300 acres on Long Island near Upton, New York. BNL is managed
and operated by a consortium of universities known as Associated Universities,
Inc., under contract with DOE. BNL conducts basic and applied research in the
physical, biomedical, and environmental sciences, as well as selected energy
technologies.
5Hardin B. Jones, M.D., was a
physician who worked with John Lawrence at the Donner Laboratory, Berkeley. He
was an early associate of John Lawrence's. He studied isotope applications in
nuclear medicine and showed uptake of iodine-131 by human and bovine thyroids.
Regarded as an excellent experimentalist, Jones became the scientific assistant
director of Donner Laboratory and led a research group. He was a member of the
National Advisory Committee on Radiation of the Federal Radiation Council. See "Reflections
on Hardin Jones" in DOE/EH-0476,
Human Radiation Studies: Remembering the Early Years; Oral History of
Physiologist Nello Pace, Ph.D. (June 1995).
6From 1946 to 1967, Pace served at
UC Berkeley as a research associate for the Division of Medical Physics and a
professor of Physiology, chairing the Department of Physiology from 1964 to
1967. He established the White Mountain Research Station near Bishop, California
in 1950, where he worked from 1950 to 1977. In 1977, he became an emeritus
professor of Physiology at UC Berkeley. Pace's research interests were in
gravitational physiology, environmental physiology, and body composition. See
DOE/EH-0476, Human Radiation Studies:
Remembering the Early Years; Oral History of Physiologist Nello Pace, Ph.D.
(June 1995).
7William Emil Siri, (1919),
a physicist, worked on the Manhattan Project at UC Berkeley from 1943 to 1945.
Afterward he conducted research at Donner Laboratory. Siri researched the
application of radioisotopes to biology and medicine. He also studied
high-altitude physiology, leading expeditions to the Peruvian Andes, the
Himalaya Mountains, and Antarctica.
8Ernest L. Dobson, Ph.D., was a
biophysicist who was born in Beijing, China, in 1914 and became a U.S. citizen.
He worked as a physiologist at the Lawrence Radiation Laboratory from 1946 until
his death, conducting research on the physiology of the circulatory system.
9R. Lowry Dobson, Ph.D., M.D., is
a physician who was born in Beijing, China, in 1919 and became a U.S. citizen.
He was a research fellow at Donner Laboratory and Lawrence Radiation Laboratory
(at UC Berkeley) and was chief medical officer until 1958. Additionally, he was
a senior scientist in the Biomedical Sciences Division at the Lawrence Livermore
National Laboratory, conducting research on the health effects of exposure to
environmental agents, radiation, and internal radionuclides.
10Dr. John Lawrence, brother of
Ernest O. Lawrence, was Director of the Division of Medical Physics at the
University of California, Berkeley. He operated a clinic at Donner Laboratory,
where he treated leukemia and polycythemia vera patients with radioactive
phosphorus.
11a device that uses deflection
of ions in an electromagnetic field as a basis for identifying the elements (or
elemental components) present in a substance
12an isotope of hydrogen, having
twice the mass of ordinary hydrogen (protium); "heavy hydrogen"
13a disease characterized by
overproduction of red blood cells
14a colorless, odorless,
poisonous gas, CO, produced when carbon burns with insufficient air
15a radioactive isotope of
hydrogen having an atomic weight of three. The heaviest isotope of the element
hydrogen, tritium gas is used in modern nuclear weapons.
16Tobias was a professor of
medical physics and radiology at the Donner Laboratory and the University of
California at Berkeley. Dr. Tobias's main research focused on the biological
effects of radiation; cancer research; and space medicine. For the transcript of
the interview with Tobias, see DOE/EH-0480,
Human Radiation Studies: Remembering the Early Years; Oral History of
Biophysicist Cornelius A. Tobias, Ph.D. (July 1995).
17Joseph Hamilton, an M.D.,
worked at Crocker Laboratory, then the site of a 60-inch cyclotron that he
operated to produce radioisotopes in support of research and some medical
diagnosis and treatment. Crocker was part of the Lawrence Radiation Laboratory.
18an accelerator in which
particles move in spiral paths in a constant magnetic field
19During World War II, the
Manhattan Project had built a vast complex of highly classified facilities in
and near Oak Ridge, Tennessee, to process uranium for use in atomic bombs. The
Atomic Energy Commission took control of these facilities upon its creation and,
today, they belong to the Department of Energy. For producing weapons-grade
plutonium, the reactor design installed at Oak Ridge proved to be significantly
less efficient than an alternative Manhattan Project design at Hanford Site.
After World War II, a decision was made to make Oak Ridge the principal source
for reactor-produced radioisotopes, a mission to which the Oak Ridge Reactor was
well-suited.
20Theodore T. Puck, D.Sc. (born
1916), a biophysicist and geneticist who was a research professor of
biochemistry, biophysics, and genetics at the University of Colorado Medical
Center in Denver from 1948 until his retirement. He was a member of the National
Academy of Sciences and a recipient of numerous awards and medals. He developed
principles of somatic cell genetics and genetic biochemistry and events leading
to cancer.
21Leo E. Farr, M.D. (born 1907),
a research physician who worked at the Rockefeller Institute Hospital (193440).
He subsequently served as director of research at du Pont Nemour Foundation,
Wilmington, Delaware (194042, 194648). He worked at the Naval
Medical Research Institute (194246); headed the medical research center at
Brookhaven (194862), worked at M.D. Anderson Hospital, University of
Houston (196267); and organized emergency medical services for the State
of California Department of Public Health, Berkeley (196773). Dr. Farr
conducted research on kidney disease; nephrosis; protein metabolism; electrolyte
imbalance; blood substitutes; deep-sea diving and submarine medicine; and the
development of applications of nuclear science to medicine. At Brookhaven, Dr.
Farr was Robertson's first supervisor and worked with Dr. William Sweet on the
boron neutron capture program for treatment of brain tumors.
22J.B. Horner (Desmond) Kuper
(born 1909), a physicist and electronics engineer who conducted research on
spectrophotometer development, Geiger counters, and other radiation detection
instrumentation. He served at the Radiation Laboratory, Massachusetts Institute
of Technology (194146). Subsequently, at Brookhaven, he headed the
Electronics Division; chaired the Instrumentation and Health Physics Department
(194770); served as assistant to the Laboratory Director; and served as a
consultant. Marietta Kuper, administrative officer to BNL Director Leland
Hayworth, was married to Desmond Kuper.
23an apparatus in which a
nuclear-fission chain reaction is sustained and controlled; research reactors
are generally smaller than production-scale reactors.
24Brain tumor patients were
injected with a discrete amount of boron that was intended to deposit in the
tumor. The tumor was then bombarded with a beam of neutrons that was directed to
the boron in the hope of destroying the tumor.
25From 1951 to 1961, Brookhaven
conducted boron neutron capture therapy on 45 patients. All were suffering from
aggressive and otherwise untreatable types of brain tumors; all had received
conventional radiation treatments. The therapy was unsuccessful. Patients
so-treated generally lived only as long as patients with the same types of brain
tumor who were treated with conventional radiation therapies. The work was
funded by the U.S. Atomic Energy Commission. Source:
Human Radiation Experiments Associated with the U.S. Department of Energy
and Its Predecessors (213 pages), DOE/EH-0491, July 1995.
26William H. Sweet, M.D., D.Sc.
(born 1910), was a neurosurgeon at Harvard University Medical School from 1940
until his retirement in the late 1970s. He conducted research on the central
nervous system, brain fluids, treatment of brain tumors, mechanisms of pain, and
behavior relating to brain disease. During the 1950s, Dr. Sweet conducted
research using boron neutron capture therapy in conjunction with Brookhaven
National Laboratory.
27Gordon L. Brownell, Ph.D. (born
1922), conducted research on the imaging of positron-emitting radionuclides and
computerized axial tomography, and the dosimetry effects of ionizing radiation.
He served as a medical physicist and professor of nuclear engineering at the
Massachusetts Institute of Technology. Brownell was a lecturer at Harvard
Medical School. From 1950 to the present he has been a physicist at the
Massachusetts General Hospital in Boston.
28elementary particles found in
the nucleus of most atoms and having no electrical charge
29Robertson is referring to
neutron activation analysis. When an element is introduced into a nuclear
reactor, radioactive isotopes will be produced as neutrons are captured into the
nucleus of the element's atoms. By measuring the radioactive emissions of these
isotopes, scientists can more easily identify the irradiated elements.
30Massachusetts Institute of
Technology, Cambridge, Massachusetts
31uncontrolled, abnormal,
circumscribed growths of cells in any tissue; neoplasms
32brain tumors characterized by
the presence of a great variety of cellular types
33the removal for diagnostic
study of a piece of tissue from a living body
34relating to the study of the
structure of tissue
35a tumor of the brain and spinal
cord originating from astrocyte cells
36tumors of the brain and spinal
cord originating in tissues that form the supporting structure of nerves
37having nephrosis, a kidney
disease marked by noninflammatory degeneration of the tubular system
38Dr. Lewis Dahl, M.D., a
physician (internal medicine) who worked at the Rockefeller Institute before
transferring to Brookhaven. He studied the relationship between salt metabolism
and hypertension.
39George Cotzias, M.D., son of
the mayor of Athens (an anti-Nazi) during the occupation of Greece by the
Germans. Educated at Harvard, Cotzias went on to work at Brookhaven circa 1952.
He is noted for his work on manganese poisoning and Parkinson's disease, and for
urging the use of high-dose L-dopa to help control Parkinson's.
40a neurologic disease believed
to be caused by deterioration of the brain cells that produce dopamine,
occurring primarily after the age of 60, and characterized by tremors
(especially of the fingers and hands), muscle rigidity, and a shuffling gait
41predecessor agency to the U.S.
Department of Energy and Nuclear Regulatory Commission (NRC); established
January 1, 1947
42one of three clinical
facilities created by the Atomic Energy Commission in 1948. While the AEC owned
the 58-bed Chicago hospital, the University of Chicago medical school
administered and staffed the facility. Patients were admitted on a selective
basis: physicians chose persons whose condition best suited the hospital's
research and treatment applications. The hospital admitted its first patient in
January 1953. The Energy Research and Development Administration terminated
Government support for Argonne and the other AEC-created research hospitals in
1974, three years after the hospital's name was changed to the Franklin McLean
Institute. The facilities are now used by the university's medical school for
studies in radiology and hematology.
43Oak Ridge Institute of Nuclear
Studies, established in 1946 by the Manhattan Engineer District and operated
under a Manhattan Project (and later Atomic Energy Commission) contract. ORINS
was responsible for training physicians and researchers in the safe handling of
radioisotopes and in the development of isotope applications in medicine. In
addition, ORINS was responsible for selecting both students and established
scientists for fellowships and other temporary research assignments.
44director of the AEC's Division
of Biology and Medicine from 1963 to 1967, when he left to take a position at
the National Academy of Medicine
45clearance from the body and
replacement by new intakes of the same materials
46an endocrine gland located at
the base of the neck and secreting two hormones that regulate the rates of
metabolism, growth, and development
47Rulon W. Rawson, M.D. (born
1908), a physician and specialist in diseases and physiology of the thyroid and
thyroid cancer. He served at Harvard Medical School, Massachusetts General
Hospital (193848), Cornell University (Ithaca, New York), and Memorial
Sloan-Kettering Cancer Center (194854). He was vice president of the
College of Medicine and Dentistry of New Jersey (195867). His research
interests were in the use of radionuclides for treatment of thyroid disease.
48an excess assimilation of
radioiodine in the thyroid, indicating abnormality
49Radioiodine (131I) is widely
used to diagnose thyroid function and also is a highly effective therapy for
hyperthyroidism, Graves' disease, and thyroid cancer.
50a radioactive tag on
biomolecules, used to study a biological, chemical, or physical system
51the process or method of
measuring or calculating the dose of ionizing radiation, or energy absorbed per
unit mass, using data from bioassay and other radiation measurements
52a millionth of a curie; a curie
represents 37 billion radioactive decays per second.
53a heavily shielded room
designed for work with radioactive materials. The technician usually stays
outside of the room and manipulates the materials by remote-controlled robotic
arms to process radioactive chemicals.
54a pilot graphite reactor and
plutonium production plant at Oak Ridge, built by Du Pont. The X-10 pile was a
graphite cube, 24 feet square. It had been drilled with 1,248 channels that
could be loaded with uranium slugs. Large fans blew cooling air through these
channels. (Source: Richard Rhodes; The Making of the Atomic Bomb; New
York: Simon and Schuster; 1986, p. 547)
55thousands of a curie; a
millicurie is one thousand microcuries.
56International Atomic Energy
Agency, an organization of the United Nations headquartered in Vienna, Austria
57residents of the Marshall
Islands, a group of 34 atolls in the west central Pacific where the United
States performed atmospheric tests of nuclear weapons in the 1950s. Since 1986
the Marshall Islands have been a self-governing area associated with the United
States.
58Edward L. Alpen, Ph.D. (born
1922), a radiobiologist and physiologist who conducted research on radiation
biology, cellular kinetics, and regulation of erythropoiesis. He served as
biophysicist, division head at Hanford Laboratories, and Director of the Pacific
Northwest Laboratory in Richland, Washington (195575), and as professor of
medical physics and assistant director of the Donner Laboratory at the
University of California, Berkeley (1975 until retirement). For recollections of
Alpen's tenure at Donner, see DOE/EH-0479,
Human Radiation Studies: Remembering the Early Years; Oral History of Donner
Lab Administrator Baird G. Whaley (September 1995).
59Victor P. Bond, M.D. (1919),
was a radiation biophysicist with the Naval Radiological Defense Laboratory
(194855) and Brookhaven National Laboratory (starting 1955). He conducted
research on the biological effects of radiation. At Brookhaven, he conducted
pioneering research in bone marrow transplants and served as an Associate
Laboratory Director.
60Stanton H. Cohn, Ph.D. (born
1920), was a physiologist and chemist at Argonne National Laboratory (194649),
a radiobiologist at the Crocker Laboratory of the University of California (194950)
and Naval Research Laboratory (195070), and head of the Medical Physics
Division at Brookhaven National Laboratory (1970 until his retirement). He
conducted research on mineral metabolism in bone, biological distribution and
effects of internally deposited radionuclides, whole-body neutron activation
analysis, and whole-body counting.
61A hydrogen bomb test, Bravo was
the first shot in the Castle Series. Detonated March 1, 1954, the size of the
blast and amount of radiation produced was said by the AEC to have been far
greater than planned. Test personnel, Marshallese islanders, and the crew of a
Japanese fishing vessel received fallout from the Bravo Test. Source:
DOE/EH-0445, Human Radiation Experiments: The Department of Energy Roadmap
to the Story and the Records (February 1995).
62an atoll in the Marshall
Islands, a group of 34 atolls in the west central Pacific where the United
States performed atmospheric tests of nuclear weapons in the 1950s
63radioactive debris from a
nuclear detonation or other source. Fallout is usually deposited from airborne
particles.
64For a researcher's account of
the field trip to assess the fallout effect on the Rongelap islanders, see "Cleanup
of the Nevada Test Site and Marshall Islanders" in DOE/EH-0463, Human Radiation Studies:
Remembering the Early Years; Oral History of Health Physicist William J. Bair,
Ph.D. (June 1995).
65Robert A. Conard, M.D. (born
1913), was a medical scientist with the U.S. Navy and the Naval Radiological
Defense Laboratory (194156) and Brookhaven National Laboratory (195679).
He conducted environmental health studies among the Marshallese exposed to
radioactive fallout.
66an apparatus that measures
radionuclides in man using shielded detectors and multichannel energy analyzers
67a highly penetrating photon of
high frequency, usually 1019 Hz or more, emitted by an atomic nucleus
68an optical device for measuring
wavelengths, deviation of refracted rays, and angles between faces of a prism
69a radioactive substance that
emits electrons or positrons during radioactive decay
70See BNL-34, "Study of the
Metabolism of Cesium-137," in Human Radiation Experiments Associated
with the U.S. Department of Energy and Its Predecessors (213 pages),
DOE/EH-0491, July 1995.
71any of several cancers of the
bone marrow characterized by an abnormal increase of white blood cells in the
tissues, resulting in anemia, increased susceptibility to infection, and
impaired blood clotting
72a chemical converted in the
brain to dopamine: used in synthetic form to treat Parkinson's disease
73Advances in technology that
deliver higher concentrations of boron to tumor tissues for potentially improved
therapy have brought about the return of boron neutron capture therapy. As a
result, Brookhaven is currently involved in BNCT research and clinical trials.
74diagnostic and therapeutic
medical techniques using radionuclides or radioisotopes
75Created in 1949 as the National
Reactor Testing Station (NRTS), INEL has served as the test site for prototypes
of many reactor designs in wide use today. INEL now operates the Advanced Test
Reactor (ATR) for engineering studies, and focuses on waste disposal and
remediation technology.
76an experimental reactor built
at the National Reactor Testing Station near Idaho Falls, Idaho. Its original
purpose was to simulate extreme operating conditions and to aid in the study of
reactor physics.
77Arthur Soloway, Ph.D., was a
chemist from Massachusetts General Hospital who synthesized the boron cage used
to deliver boron atoms to brain tumors during early studies on boron neutron
capture therapy at Brookhaven.
78Hiroshi Hatanaka, M.D, a
Japanese physician who conducted pioneering work in boron neutron capture
therapy for brain cancer
79New treatment modalities may be
attempted on the basis of emergency or "compassionate" need. Food and
Drug Administration approval is needed for further clinical trials after an
application has been accepted for an "investigational new drug" (IND),
radiopharmaceutical, or procedure.
80The current plan is to test
BNCT on a series of about 20 brain tumor patients.
81Irving Ariel, M.D., a physician
at the Memorial Hospital (Memorial Sloan-Kettering Cancer Center) in New York
City who was interested in combinations of radiation and surgery for treating
abdominal cancers. He collaborated with Brookhaven scientists to develop
palladium for irradiation after surgery.
82Harold L. Atkins, M.D. (born
1926), a physician in nuclear medicine at the State University of New York,
Stony Brook. Atkins collaborated in radiation research with the medical
department at Brookhaven National Laboratory.
83thermal neutronsneutrons
that have slowed down by energy loss (collisions) to about 0.025 to 0.04
electron-volt at room temperature
84epithermal neutronsneutrons
that have slowed by energy loss to energies above the thermal level (1 to 100
electron-volts)
85a radioactive, luminous white,
metallic element that occurs in very small quantities in combination with
minerals. Radium had been used in treating cancer. At that time, no radioisotope
had been more thoroughly characterized for its biomedical effects.
86A pioneer in radiation therapy,
Robert Stone, M.D., had conducted human radiation studies before World War II.
He was an early researcher at the Lawrence Radiation Laboratory and became a
major figure in radiobiology research. When Joseph Hamilton began operating his
60-inch cyclotron at Crocker Laboratory, Stone requested that fission products
be made on the cyclotron and that their fate in mammals be systematically
studied in small animals. That information would be used for radiation
protection proposes. In 1942, while chairing the Department of Radiology at UC
San Francisco's medical school, Stone was recruited to lead the Medical Division
of the Manhattan Project, overseeing all biological, medical, and radiological
protection research. Accordingly, he moved to the University of Chicago, where
he served as Associate Director for Health under Arthur Compton. In the 1950s,
after serving in the Atomic Energy Commission, Stone returned to his post at the
UC San Francisco as head of the Department of Radiology. Under Stone, UCSF
acquired a 70-MeV synchrotron for conducting therapeutic research.
87treatment and observation of
living patients, as distinguished from research
88ERDA succeeded the AEC in the
early '70s, and in turn was replaced by the DOE in 1977.
89The Nuclear Medicine Program
Office was part of the office of Health and Environmental Research at DOE.
90the branch of medicine dealing
with the statistics of incidence and prevalence of disease in large populations
and with detection of the source and cause of epidemics; also: the
factors contributing to the presence of absence of a disease
91a particle with the mass of the
electron but with a positive electric charge
92positron emission tomography
(PET) scannera device that produces computerized three-dimensional images
of biochemical activity in the brain or other organ through use of radioactive
tracers that emit positrons and twin 0.511-MeV gamma rays; the detectors
measured the accompanying 0.511-Mev gamma rays emitted during positron decay.
93Los Alamos Scientific
Laboratory was a key research and development center for the Manhattan Project.
Nuclear bombs were assembled there before and during the Cold War. It has been a
research and development center for nuclear weapon designs. Renamed Los Alamos
National Laboratory, it is now a part of the U.S. Department of Energy, operated
by the University of California.
94an accelerator that accelerates
particles in a straight line, often miles long, instead of in a closed loop
95use of a special radiation
detector that matches two simultaneous emissions from a single radioactive decay
96a device that measures
radioactivity by registering the number of scintillations (ionizations of a
phosphor struck by a photon or energetic particle) it produces
97Anger cameras, large, flat
circular crystals of thallium-activated sodium iodide, backed with
photomultiplier tubes arranged in honeycomb geometry, for obtaining an image of
gamma emitting pharmaceutical in the patient; named for its inventor, Hal Anger,
of the University of California at Berkeley. The cameras are still widely used
in modern nuclear medicine clinics to image gamma-emitting radiopharmaceuticals
used in the diagnosis of cancer and other diseases.
98Single Photon Emission Computed
Tomography (SPECT)a detector system resembling a gamma camera that rotates
around a central axis; computer algorithms generate a two-dimensional image by
analyzing photon attenuations from a radioactive source material distributed
nonuniformity in the patient.
99For the transcript of the
December 30, 1994, interview with Hubner, see DOE/EH-0470,
Human Radiation Studies: Remembering the Early Years; Oral History of
Hematologist Karl F. Hubner, M.D. (September 1995).
100From 1951 to 1977, Durbin
worked as a chemist and radiobiologist at the Crocker Laboratory of the Lawrence
Radiation Laboratory (Lawrence Berkeley Laboratory). For the transcript of the
November 11, 1994, interview with Durbin, see DOE/EH-0458,
Human Radiation Studies: Remembering the Early Years; Oral History of Dr.
Patricia Wallace Durbin, Ph.D. (June 1995). Durbin discusses her strontium
research in three sections of her interview: "Potential Influences of
Monkey Studies in Strontium Metabolism in Humans," "Human Strontium
Injection Studies," and "Study of Calcium and Strontium Metabolism in
Human Infants."
101From 1958 to 1959, scientists
at the U.S. Naval Radiological Defense Laboratory and at UC Berkeley's Donner
Laboratory collaborated in a study of lean-body weight and skeletal size in
humans. The purpose of this study was to determine reference values for normal,
healthy individuals. Thirty-one healthy Navy personnel served as subjects for a
study of lean-body weight, total-body water, and skeletal size. See LBL-75, "Estimates
of Lean-Body Weight and Skeletal Size Using Tritium and X-Rays," in Human
Radiation Experiments Associated with the U.S. Department of Energy and Its
Predecessors (213 pages), DOE/EH-0491, July 1995.
102The bends are caused by tiny
air bubbles released into tissue by a too-rapid decrease in air pressure after
staying in a compressed atmosphere, such as the too-rapid ascent of a diver from
deep in the sea to normal atmosphere at sea level. It is potentially fatal.
103the blocking of a blood
vessel by a clump of tissue, a bubble, fat globule, or other substance that has
lodged in a blood vessel
104Eugene P. Cronkite, M.D.
(born 1914), a physician and hematologist at the Naval Medical Research
Institute (194654) and Brookhaven National Laboratory (195479). He
conducted research on control of hemopoiesis in health and disease conditions.
105a type of white blood cell
important in the production of antibodies
106Acute lymphoblastic leukemia
comprises 90 percent of childhood leukemia, but is uncommon in adults. It is
manifested by elevated white blood cell counts and blasts in circulation, and
causes fatigue, bone pain, bleeding, and easy bruising.
107for example, chronic
lymphocytic leukemia, an accumulation of immunologically incompetent lymphocytes
in the circulatory system, leading to enlarged spleen, fatigue, increased
susceptibility to infections, and conversion to high-grade lymphoma
108Iron-55 has a half-life of
2.94 years; iron-59, 45.1 days. Unlike iron-55, iron-59 emits beta and gamma
radiation.
109The National Aeronautics and
Space Administration (NASA) sought to determine whether astronauts should be
protected from the radiation flux in the Van Allen belts and from radiation in
space in the event of a highly energetic stellar event (such as a supernova).
Such exposures, NASA calculated, would amount to about 1.5 roentgens (R) per
hour. Some LETBI patients would receive similar rates of exposure for days at a
time, as astronauts might. Accordingly, NASA paid ORINS to report on the effects
of such exposure on patients in order to develop techniques that could be used
to diagnose whether an astronaut was developing radiation sickness. The funding
led to charges that NASA was dictating the exposure rates that the LETBI staff
administered to patients. See "NASA Support for LETBI Research" in the
Vodopick transcript (DOE/EH-0482, August
1995), and "NASA-Sponsored Studies" and "Questioning the
Propriety of NASA-Funded Studies" in the Lushbaugh transcript (DOE/EH-0453, April 1995).
110Clarence Lushbaugh directed
the Low-Exposure-Rate Total Body Irradiator (LETBI) facility. For contrasting
views on the medical ethics of those studies, see DOE/EH-0475, Human Radiation Studies:
Remembering the Early Years; Oral History of Health Physicist Karl Z. Morgan,
Ph.D. (June 1995) and DOE/EH-0453, Human
Radiation Studies: Remembering the Early Years; Oral History of Pathologist
Clarence Lushbaugh, M.D. (April 1995).
111the soft, fatty, vascular
tissue in the cavities of bones; it is a major site of blood-cell production.
112For a discussion of the Oak
Ridge bone-marrow transplant research, see DOE/EH-0453,
Human Radiation Studies: Remembering the Early Years; Oral History of
Pathologist Clarence Lushbaugh, M.D. (April 1995).
113relating to metastasis, the
spread of disease-producing organisms or of malignant or cancerous cells to
other parts of the body by way of the blood or lymphatic vessels or membranous
surfaces
114a portable instrument for
detecting ionizing radiation and measuring dose rate
115Pi mesons (or pions) are
subatomic particles responsible for the strong interactions between protons and
neutrons in atomic nuclei. Mesons occur in pairs, and are liberated during the
high-energy bombardment in accelerators. They have very high energy (140 MeV to
10,000 MeV) and are short-lived. Researchers have used pi mesons for cancer
therapy with some success. See "Pion Irradiation Therapy at Los Alamos
(1974)" in the Voelz transcript (DOE/EH-0454),
May 1995. and "Grilly's Comments on Negative Perceptions of Los Alamos and
of Radiation Research" in the Julie Langham Grilly transcript (DOE/EH-0469, September 1995).
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