(1)Dr. Petersen has worked at Los Alamos since 1956,
originally in Group H-4, Radiobiology (later renamed Bio-Medical Research) under
Wright Langham. From 1964 to 1981, he served successively as the Cell Biology
Section Leader and Group Leader, Alternate Health Division Leader, and Acting
Life Sciences Division Leader. Since 1981 he has been the Program Manager for
the Chemical and Biological Program. For the transcript of the November 29, 1994
interview with Petersen, see DOE/EH-0460,
Human Radiation Studies: Remembering the Early Years; Oral History of Cell
Biologist Don Francis Petersen, Ph.D. (August 1995).
(2)originally Los Alamos Scientific Laboratory, a
key research and development center for the Manhattan Project. Nuclear bombs
were assembled there before and during the Cold War. It has been a research and
development center for nuclear weapon designs. Renamed Los Alamos National
Laboratory, it is now a part of the U.S. Department of Energy, operated by the
University of California.
(3)a physician specializing in the diagnosis and nonsurgical
treatment of diseases
(4)a branch of microbiology dealing with bacteria
(5)the branch of biology dealing with microscopic
organisms
(6)a member of the U.S. armed forces, especially a soldier
(7)Langham, regarded at the time as "Mr.
Plutonium," led the Health Division's Radiobiology Group from 1947 until
his death in 1972.
(8)In a May 1947 reorganization, the research functions of
the Health Group became the responsibility of a new group, H-4 (Radiobiology),
under the direction of Wright Langham. During the late 1940s and early 1950s,
research with human subjects at Los Alamos was limited to tritium studies. The
human subjects were researchers in Group H-4. In 1949, the group's name was
changed to Bio-Medical Research. By 1972, H-4 had grown to 70 staff members
working in molecular biology, cellular radiobiology, mammalian biology,
biophysics, veterinary biology, and pathology.
(9)the study of the structure of tissue
(10)Mitotic indices are parameters for evaluating
chromosome replication during the process of cell division.
(11)the middle portion of the small intestine, between
the duodenum and the ileum
(12)the adrenal glandsa pair of ductless glands,
located above the kidneys, that produces steroidal hormones, epinephrine, and
norepinephrine
(13)an instrument used in the laboratory to measure photons,
a quantum of electromagnetic radiation, usually considered as an elementary
particle that is its own antiparticle and that has zero rest mass and charge and
a spin of one
(14)a technique whereby photographic film is placed over
thinly sliced tissue to record, in image form, the radiation tracks from the
tissue that pass through the film's emulsion
(15)a renowned histologist, chair of the Department of
Anatomy, University of Chicago
(16)bone that has not been deprived of lime or
calcium-bearing matter
(17)developed or maintained in a controlled, nonliving
environment, such as a test tube; Latin for "in water"
(18)incorporated with a radioactive isotope to make a
substance traceable, from a source material administered intravenously (into the
blood)
(19)an excess assimilation of a radioisotope, indicating
abnormality
(20)Dr. Clarence C. Lushbaugh, M.D., Ph.D.H-4 staff
member from 1949 to 1963. Chief Scientist of the Medical and Health Sciences
Division at Oak Ridge National Laboratory, 1963 to 1975, and Chairman of the
Medical and Health Sciences Division at Oak Ridge, 1975 to 1984. For the
transcript of the interview with Lushbaugh, see DOE/EH-0453, Human Radiation Studies:
Remembering the Early Years; Oral History of Pathologist Clarence Lushbaugh,
M.D. (April 1995).
(21)Colonel John Pickering was a researcher at Brooks Air
Force Base in charge of monkey irradiation.
(22)one of the geographical experiment sites at Los Alamos
(23)an atoll in the Marshall Islands, a group of 34 atolls
in the west central Pacific where the United States performed atmospheric tests
of nuclear weapons in the 1950s
(24)the first of three series of nuclear weapon tests
conducted at the Pacific Test Range. Operation Greenhouse included four tests
detonated between April 7 and May 24, 1951, from towers at Eniwetok Atoll in the
Marshall Islands. The only confirmed blast yield was for Shot Easy, said to be
in the 47-kiloton range (Source: U.S. Nuclear Tests, July 1945 Through
December 1988; U.S. Department of Energy Nevada Operations Office; September
1989).
(25)To collect data on nuclear effects, 15,000 animals were
reportedly used in the Greenhouse series.
(26)an instrument for cutting very thin sections of tissue
for microscopic examination
(27)HUMCO I was the first whole-body radiation counter that
became operational at Los Alamos National Laboratory in 1956; the sensitivity
and noninvasiveness of this new instrument permitted studies at levels 10 to 100
times below established limits of exposure. It opened an entire area of clinical
diagnosis and the development of new diagnostic methods, mostly by Lushbaugh.
(28)a radioactive isotope of hydrogen having an atomic
weight of three. The heaviest isotope of the element hydrogen, tritium gas is
used in modern nuclear weapons.
(29)a physician with a degree in Physics. Mathematically
gifted, Harris performed a good deal of support work for studies at the Nevada
Test Site.
(30)Eberline Instrument Corp., Santa Fe, New Mexico, maker
of radiation detection instrumentation and portable counters
(31)a physician who studies the study of the origin, nature,
and course of diseases
(32)the branch of biology dealing with the functions and
activities of living organisms and their parts
(33)a physician who treats and observes living patients, as
distinguished from one engaged in research
(34)During World War II, the University of Chicago ran a
toxicity laboratory for the U.S. Army Chemical Corps to conduct research in
chemical warfare. From 1948 until 1951, the Atomic Energy Commission used the
facility for radiological warfare research. In 1948, the AEC worked with the
Army and the university on a research program for the laboratory that focused on
the poisonous effects of radiation exposure. Animal research was conducted on
the local effects and general toxicity of radioisotopes considered for use as
radiological warfare agents.
(35)Lushbaugh explains in his oral history: "I
discovered that the nitrogen mustards were lymphotoxic
(36)From 1944 to 1962, Los Alamos conducted 254 open-air
implosion physics tests in nearby Bayo Canyon. The purpose of the program was to
test weapons designs using conventional high explosives and radioactive
lanthanum (RaLa), a short-lived but intense radiation source. Tests were
performed specifically to diagnose material motion and compression through
high-speed x-ray photographs of the earliest moments of the implosion. The
sources involved contained quantities ranging from around one hundred to several
thousand curies of lanthanum-140.
(37)a highly penetrating photon of high frequency, usually
1019 Hz or more, emitted by an atomic nucleus
(38)loss of coordination of the muscles, especially of the
extremities
(39)Ethylene diaminetetraacetic acid is a chelating agent
for several heavy metal cations.
(40)Joseph Hamilton, an M.D., worked at Crocker Laboratory,
then the site of a 60-inch cyclotron that he operated to produce radioisotopes
in support of research and some medical diagnosis and treatment.
(41)a chemical agent that removes heavy metals from the
bloodstream and soft tissues and carries them to excretion (urine)
(42)For the transcript of the interview with Voelz, see
DOE/EH-0454, Human Radiation Studies:
Remembering the Early Years; Oral History of Dr. George Voelz, M.D. (May
1995)
(43)After med school, Voelz served at Los Alamos under Dr.
Thomas Shipman, the Health Division leader. Voelz's initial year was part of an
in-plant training program for the practical application of industrial medicine.
He stayed on for another three and a half years in a staff position in the
Application Medicine Group at the Los Alamos Scientific Laboratory.
(44)Created in 1949 as the National Reactor Testing Station
(NRTS), INEL has served as the test site for prototypes of many reactor designs
in wide use today. INEL now operates the Advanced Test Reactor (ATR) for
engineering studies, and focuses on waste disposal and remediation technology.
(45)Hempelmann was a group leader in the Health Division at
Los Alamos Scientific Laboratory from 1943 to 1947, and led the division from
1946 to 1948. An expert in radiology and radiobiology, Hempelmann served in the
Atomic Energy Commission from 1948 to 1950, then joined the faculty of the
University of Rochester.
(46)a 40-percent solution of formaldehyde, used as an
antiseptic and disinfectant in dilute solution and as a fixing agent for
histological specimens
(47)Formed in a May 1947 reorganization, the "H"
or Health Division had responsibility for a much broader range of health
activities than its predecessor, the Health Group (Group A-10). These
responsibilities included radiological safety, health physics, and industrial
health. The H Division also monitored exposures and was responsible for safety
for all weapons tests conducted by the Laboratory.
(48)leader of the Health Division at Los Alamos National
Laboratory and the Lab's Medical Director
(49)The Administrative Division had been set up by J. Robert
Oppenheimer during the Manhattan Project. It was responsible for such activities
as health, procurement, and patents.
(50)an accelerator in which particles move in spiral paths
in a constant magnetic field
(51)U.S. physicist, 190158; a pioneer in nuclear
physics who built and operated (with M. Stanley Livingston and Milton White) the
first cyclotron in 1930 on the Berkeley campus of the University of California;
established the University of California Radiation Laboratory in 1936 and served
as its director until his death. His ingenuity and drive made the Berkeley-based
Radiation Laboratory the unofficial capital of nuclear physics in the United
States.
(52)high-energy physics research activities, which
typically require large, costly facilities and large teams of scientists and
engineers
(53)J. Robert Oppenheimer, U.S. nuclear physicist (190467)
who was chosen by General Leslie Groves to direct the development and
construction of the atomic bombs at Los Alamos, New Mexico
(54)Metallurgical Laboratory, the laboratory set up at the
University of Chicago during World War II to lead the secret research and
development of controlled nuclear fission under the Manhattan Project; in
particular, the design of reactor facilities and the chemical separation of
uranium, plutonium, and fission products from irradiated nuclear fuels
(55)a professor of Radiology at the University of Rochester
(Rochester, New York), site of research involving plutonium and human subjects.
Dr. Warren worked on the Manhattan Project in Oak Ridge as head of the medical
section and headed an Intramedical Advisory Committee. After World War II, he
became dean of the University of California, Los Angeles Medical School.
(56)A microgram is one-millionth of a gram; there are about
28.35 grams in one troy ounce.
(57)General Leslie R. Groves, of the U.S. Army, assumed
command of the Manhattan Engineer District in 1942 and led it to completion of
the Manhattan Project.
(58)During World War II, the Manhattan Project had built a
vast complex of highly classified facilities in and near Oak Ridge, Tennessee,
to process uranium for use in atomic bombs. The Atomic Energy Commission assumed
control of these facilities upon its creation and, today, they belong to the
Department of Energy.
(59)From 1951 to 1977, Durbin worked as a chemist and
radiobiologist at the Crocker Laboratory of the Lawrence Radiation Laboratory
(Lawrence Berkeley Laboratory). For the transcript of the November, 11, 1994
interview with Durbin, see DOE/EH-0458,
Human Radiation Studies: Remembering the Early Years; Oral History of Dr.
Patricia Wallace Durbin, Ph.D. (June 1995).
(60)a weekly tabloid generally regarded as sensationalist in
its coverage and treatment of news
(61)On January 17, 1966, an accident occured between two
U.S. Air Force jet aircraft: a KC-135 tanker and a B-52 bomber carrying four
thermonuclear weapons. Two of the weapons were found intact. The other two
experienced non-nuclear explosions that resulted in the release of some fissile
fuel and some burning. The United States and Spain, in a joint effort, performed
remedial actions and instigated a long-term program to monitor the cleanup.
(62)The United States was concerned with the public
perception of the accident and the effect of the accident on its relations with
Spain.
(63)the first test detonation of a nuclear weapon, conducted
at Alamogordo Bombing Range in New Mexico, July 16, 1945
(64)Italian-born physicist under whose leadership the
Chicago researchers produced the first sustained nuclear chain reaction on
December 2, 1942
(65)(1908), Hungarian-born refugee physicist and the "Father
of the Hydrogen Bomb." In the early 1980s, Teller became the leading
proponent of advanced strategic defenses (which he argued should be based on
nuclear weapons) as morally preferable to offensive, retaliation-based
deterrence.
(66)The 1954 decision to revoke Oppenheimer's clearance
polarized the scientific community, large segments of which ostracized Edward
Teller, who was seen has having abetted that action, for many years.
(67)From early in the Manhattan Project, friction developed
and grew between Teller and Oppenheimer. Teller favored development of the
hydrogen bomb; Oppenheimer opposed it. After World War II, Oppenheimer's
strength of reputation in the scientific community came to be seen as a major
threat by H-bomb proponents. In July 1954, the AEC revoked his security
clearance. Teller, who led the U.S. development of the hydrogen bomb, presented
views critical of Oppenheimer that contributed to the AEC decision. However, the
decision in the complex matter, in which no security lapses by Oppenheimer were
ever proven, has come to be widely regarded as less a result of objective
deliberation than of differences over early Cold War national security policy,
professional rivalry, and personal animosity. Oppenheimer's pre-war associations
with Communist front groups dogged him through the war years. Oppenheimer also
challenged a broader national security policy at a critical time. Speaking
before the Council on Foreign Relations in February 1953, he opposed the
emergent U.S. nuclear retaliatory deterrent policy on practical and moral
grounds, favoring instead a defensive strategy. This position exacerbated
friction with proponents of the H-bomb, by then at the center of scientific
influence on national security policy once occupied by Oppenheimer.When the
Soviets detonated their first hydrogen bomb in August 1953, the event
accelerated the development of U.S. nuclear weapons and cast Oppenheimer in the
position of having contributed to earlier paralysis in decision making. Sources:
John Major, The Oppenheimer Hearing, Stein and Day, New York, 1971; and
Peter Goodchild, J. Robert Oppenheimer, Shatterer of Worlds, Houghton
Mifflin, Boston, 1981.
(68)AEC Chairman Strauss is reported to have determined to
punish Oppenheimer for having opposed him, in scathing terms, during testimony
favoring the export of radioactive isotopes in 1949. Oppenheimer's 1953 speech
before the Council on Foreign Relations (discussed in preceding footnote)
further focused opposition to him in the AEC. Strauss, known for his politically
conservative views, initiated the hearing on Oppenheimer's clearance and
approved the decision. In 1959, Strauss was nominated by President Eisenhower to
be Secretary of Commerce. Two Los Alamos scientists testified in opposition,
citing three cases, including Oppenheimer's, in which they said Strauss had
abused the AEC security program to punish employees who opposed his views.
Strauss's nomination was barely reported out of committee and was defeated in a
vote of the full U.S. Senate. Sources: Major, ibid., and Goodchild, ibid.
(69)a famous American radio newscaster
(70)the playboy son of the spiritual leader of millions of
Muslims. A Pakastani, Khan was married to American actress Rita Hayworth from
1949 to 1951.
(71)Willard, in which thousands of rats are loosed
upon a city by an angry psychopath.
(72)radioactive debris from a nuclear detonation or other
source. Fallout is usually deposited from airborne particles.
(73)an American chemist who researched physical, inorganic,
and nuclear chemistry and radiochemistry. He worked at Los Alamos in the late
'40s and early '50s and received the Nobel Prize in Chemistry in 1960 for the
discovery of radiocarbon datingthe practice of measuring the ratio of
radiocarbon to stable carbon to establish the approximate age of an artifact,
region, etc.
(74)a Federally Funded Research and Development Center
(FFRDC) based in Santa Monica, California. RAND analysts are called on by the
Department of Defense and other Government agencies to analyze complex technical
and interdisciplinary problems; RAND was the prime contractor for the Greenhouse
project that Willard Libby started.
(75)Ernest Carl Anderson was a physical chemist who worked
at the University of Chicago Metallurgical Laboratory during the Manhattan
Project, 194244, and then at Los Alamos Scientific Laboratory. Dr.
Anderson received the AEC's E.O. Lawrence Award in 1966. He conducted research
in natural radiocarbon, liquid scintillation counters, low-level radioactivity
measurements, and cellular biochemistry. He also designed the HUMCO II, an
improved version of the first whole-body counter, HUMCO I.
(76)the practice of measuring the ratio of radiocarbon to
stable carbon to establish the approximate age of an artifact, region, etc.
(77)apparatuses that measure radionuclides in man using
shielded detectors and multichannel energy analyzers
(78)Project Sunshine was initiated by the AEC in response to
the urgent need for radiation biomedical information. The Project began as an
evaluation of the hazards associated with nuclear war and grew into a worldwide
investigation of radioactive fallout levels in the environment and in human
beings.
(79)Dr. Randolph Lovelace was the director of the Lovelace
Foundation and Hospital in Albuquerque. He was intimately involved in the
clinical aspects of health and well-being of workers involved in overpressure
tests.
(80)a flash of light from the ionization of a phosphor
struck by an energetic photon or particle
(81)measuring radioactivity by registering the number of
scintillations it produces
(82)From 1955 to 1958, Richmond was an assistant, then a
staff member, at Los Alamos Scientific Laboratory. In 1958, Dr. Richmond was
appointed to the staff of the Atomic Energy CommissionDivision of Biology
and Medicine in Washington, D.C., where he remained until returning to LASL in
1971 to head the Biomedical Research Group. For the transcript of the January
24, 1995 interview with Richmond, see DOE/EH-0477,
Human Radiation Studies: Remembering the Early Years; Oral History of
Radiobiologist Chet Richmond, Ph.D. (August 1995).
(83)a series of chemical compounds that scintillate when
irradiated. The use of one oxazoleterphenylfor scintillation
counting was pioneered at Los Alamos in the '50s. Terphenyl remains a staple for
scintillation counters.
(84)a device for sorting individual cells, flowing in a fine
stream, based on their physical characteristics
(85)a physicist at Los Alamos who had come from MIT
(86)In the 1950s at Los Alamos, he worked with Van Dilla to
run the development of instrumentation for cell growth experiments.
(87)Dean was in charge of operating and refining the HUMCO
II whole-body counter during its early development.
(88)DP West was the site of the early plutonium chemistry
labs before the CMR building was built.
(89)For the transcript of the interview with Cohn, see
DOE/EH-0464, Human Radiation Studies:
Remembering the Early Years; Oral History of Biochemist Waldo E. Cohn, Ph.D.
(June 1995).
(90)the U.S. Atomic Energy Commission, predecessor agency to
the U.S. Department of Energy and Nuclear Regulatory Commission (NRC);
established January 1, 1947
(91)Naval Radiological Defense Laboratory in Hunters Point
near Oakland, California
(92)the practice of taking a photograph through a microscope
(93)a multiatom particle of radioactive material that emits
many alpha or beta particles
(94)The hot particle project arose in response to a concern
that, if a nuclear-powered rocket would abort before leaving the atmosphere,
particles of plutonium would rain down to earth, be inhaled, and and lodge in
people's lungs. The project is discussed at length in "Dr. Langham's
Postwar Studies of Plutonium" in the Petersen transcript (DOE/EH-0460).
(95)dosimeters worn routinely to measure accumulated
personal exposure to radiation on photographic film
(96)For the transcript of the interview with Gamertsfelder,
see DOE/EH-0467 (September 1995).
(97)Grilly is referring to the Rover experiments, a research
and development program initiated by the AEC and the U.S. Air Force in 1957 to
develop nuclear rocket propulsion. The National Aeronautics and Space
Administration (NASA) replaced the Air Force as cosponsor in 1960. AEC had
responsibility for the nuclear aspects of the program. AEC work was assigned to
Los Alamos Scientific Laboratory and Lawrence Radiation Laboratory; field
experimentation was conducted at Jackass Flats, Nevada. The Kiwi series of
experimental reactors was part of Project Rover. The relatively long development
lead time associated with nuclear rocket propulsion caused the program to lose
funding priority to chemical rockets in the 1960s. Source: Linda Neuman Ezell,
NASA Historical Data Book, Vol. II: Programs and Projects 19581988;
National Aeronautics and Space Administration; Washington, D.C.; 1988; p. 473.
(98)On January 21, 1968, a B-52 airplane from the U.S.
Strategic Air Command crashed in Bylot Sound, 7 miles (11 kilometers) west of
Thule Air Force Base in Greenland. Due to the impact of the plane, the chemical
explosive in the four unarmed nuclear weapons onboard the aircraft detonated,
causing the release of kilograms of plutonium into the environment.
(99)soft boots worn by Eskimos, often lined with fur and
usually made of sealskin or reindeer skin
(100)ERDA succeeded the AEC in the early '70s, and in turn
was replaced by the DOE in 1977.
(101)a broad-scale program sponsored by the National
Institutes of Health and the Department of Energy to map the location of every
gene of all 47 human chromosomes
(102)the tracks recorded on photographic film by emitted
alpha particles as they would streak by
(103)A nanocurie is a billionth of curie (10-9); a curie is
a unit of measure expressing activity of radioactive substances. A curie denotes
37 billion radioactive decays per second.
(104)millionths of a curie
(105)Los Alamos Medium Energy Physics Facility, an
accelerator facility that has been used in a number of studies to investigate
the potential for accelerated particles in cancer therapy. Construction was
completed in the early '70s. The clinical part of the studies was conducted by
the University of New Mexico. Dr. Mort Kligerman, who directed the university's
Tumor Registry, served as the principal investigator. Patients were selected by
the university nationwide for the clinical trial, received clinical workups at
the university, then came to LAMPF for their radiation treatment.
(106)A meson is a fundamental particle of matter. A meson
facility is an accelerator used for causing atomic collisions that produce pi
mesons for therapy applications and other scientific investigations in
high-energy physics.
(107)copper porphyrin dye, selectively taken up by cancer
cells
(108)an example of a vital dye that turns living cells blue
without killing them, used for staining sections for tumor diagnosis and
pathology
(109)Pi mesons (or pions) are subatomic particles
responsible for the strong interactions between protons and neutrons in atomic
nuclei. Mesons occur in pairs, and are liberated during the high-energy
bombardment in accelerators. They have very high energy (140 MeV to 10,000 MeV)
and are short-lived. Researchers have used pi mesons for cancer therapy with
some success. See "Pion Irradiation Therapy at Los Alamos (1974)" in
the Voelz transcript (DOE/EH-0454), May
1995.
(110)the rapid increase in relative specific ionization of
a charged particle per unit pathlength near the end of its path in matter
(111)one of three clinical facilities created by the Atomic
Energy Commission in 1948. While the AEC owned the 58-bed Chicago hospital, the
University of Chicago medical school administered and staffed the facility.
Patients were admitted on a selective basis: physicians chose persons whose
condition best suited the hospital's research and treatment applications. The
hospital admitted its first patient in January 1953. The Energy Research and
Development Administration terminated Government support for Argonne and the
other AEC-created research hospitals in 1974, three years after the hospital's
name was changed to the Franklin McLean Institute. The facilities are now used
by the university's medical school for studies in radiology and hematology.
(112)Oak Ridge Institute of Nuclear Studies, established in
1946 by the Manhattan Engineer District and operated under a Manhattan Project
(and later Atomic Energy Commission) contract. ORINS was responsible for
training physicians and researchers in the safe handling of radioisotopes and in
the development of isotope applications in medicine. A research hospital the
Medical Division at ORINS. One of three AEC-supported hospitals, the facility
had approximately 30 beds for people with certain types of cancer.
(113)Division of Biology and Medicine (of the Atomic Energy
Commission)
(114)director of the Biology Division of Oak Ridge National
Laboratory (ORNL)
(115)Petersen discusses the concern over strontium's
fallout threat in the section, "Nuclear Weapons Fallout Studies (194654),"
in his oral history.
(116)Duke later died of cancer at a relatively young age.
(117)R. Lowry Dobson, Ph.D., M.D., a physician who was born
in Beijing, China, in 1919 and became a U.S. citizen. He was a research fellow
at Donner Laboratory and Lawrence Radiation Laboratory (at UC Berkeley) and was
chief medical officer until 1958. Additionally, he was a senior scientist in the
Biomedical Sciences Division at the Lawrence Livermore National Laboratory,
conducting research on the health effects of exposure to environmental agents,
radiation, and internal radionuclides.
(118)Shields Warren, M.D., was Chief Pathologist at New
England Deaconess Hospital and Professor of Pathology at Harvard Medical School.
He joined the U.S. Navy Medical Department in 1939 and wrote with others on what
was then known about radiation during World War II. Dr. Warren served on the
first U.S. team to visit Hiroshima and Nagasaki after they were bombed with
atomic weapons and was involved in creating what became the Atomic Bomb Casualty
Commission. He was the first director of the AEC's Division of Biology and
Medicine and, later, established his own cancer research institute at New
England Deaconess Hospital.
((119)Langham was killed in an airplane accident, Ross Air,
departing Albuquerque for Los Alamos, on May 19, 1972.
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