(1)UC Radiation Laboratory; renamed Lawrence Radiation
Laboratory; now Lawrence Berkeley Laboratory, a national laboratory of the U.S.
Department of Energy; founded by Ernest Lawrence in 1936
(2)a laboratory set up at the UC Radiation Laboratory in
Berkeley during the 1930s specifically to conduct experiments in medical physics
(3)Dr. John Lawrence, brother of Ernest O. Lawrence, was
Director of the Division of Medical Physics at the University of California,
Berkeley. He operated a clinic at Donner Laboratory, where he treated leukemia
and polycythemia vera patients with radioactive phosphorus.
(4)Mr. Whaley added later: "We used to joke a bit
that one of Dr. Lawrence's principal ways of concluding an interview was to hire
people. He had a little difficulty sometimes in saying 'no'."
(5)Mr. Whaley added later: "He was the director until
1970, and then went on the Regents."
(6)the U.S. Atomic Energy Commission, predecessor agency
to the U.S. Department of Energy and Nuclear Regulatory Commission (NRC);
established January 1, 1947
(7)Lawrence Livermore National Laboratory, Livermore,
California
(8)John Gofman was a physician and biophysicist. For the
interview with Gofman, see DOE/EH-0457, Human Radiation Studies: Remembering
the Early Years; Oral History of Dr. John W. Gofman, M.D. (June 1995).
(9)The Biomedical Division at Lawrence Livermore was set
up in 1962 by the chairman of AEC's Division of Biology and Medicine, Charles
Dunham. The establishment of this laboratory is discussed under "Livermore
Biomedical Division; Conflicts With John Gofman (196272)" in the John
R. Totter transcript (DOE/EH-0481, September 1995). For insight into discussions
leading to establishing this laboratory from Dr. Gofman's perspective, see "Establishing
Livermore Laboratory's Division of Biology and Medicine" and "Jack,
all we want is the truth" in the Gofman transcript (DOE/EH-0457, June
1995).
(10)Lawrence belonged to the Bohemian Club, an
exclusive social club in the San Francisco area known for back-to-nature
retreats at the Bohemian Grove (North of San Francisco, in the Russian River
country) and the power and influence of its members.
(11)a firm that develops and manufactures drugs approved
for human use
(12)Lilly has not merged with or been acquired by
another firm.
(13)Merck & Co., Inc., based in White House
Station, New Jersey, remains one of the largest pharmaceutical firms in the
United States.
(14)Mr. Whaley added later: "I went back and helped
with a lawsuit in 1990. And using my recollection of things that had gone on in
the late seventies and early eighties, I was surprised at the number of things
that I had forgotten or I hadn't remembered quite correctly."
(15)The U.S. Energy Research and Development
Administration succeeded the AEC in the early '70s, and in turn was replaced by
the DOE in 1977.
(16)U.S. Department of Energy, created in 1977
(17)Mr. Whaley added later: "When I speak of 'our
office,' that included Jim Born, who was the assistant director. He was also
heavily involved in the medical research end of it; and Janice DeMoor was a
physiologist. [Though she moved away shortly after I joined the Lab,] she is
certainly somebody you should talk to, and was there longer than I was. I think
she's still alive and functioning and lives here in Berkeley."
(18)an accelerator in which particles move in spiral paths
in a constant magnetic field
(19)Joseph Hamilton, an M.D., worked at Crocker
Laboratory, then the site of a 60-inch cyclotron that he operated to produce
radioisotopes in support of research and some medical diagnosis and treatment.
Crocker was part of the Lawrence Radiation Laboratory.
(20)The rivalry between Crocker and Donner, two branches
of the Lawrence Radiation Laboratory, is discussed by Gofman in the transcript
of his interview (DOE/EH-0457).
(21)Gofman's public views and outspoken style
brought him into frequent conflict with the AEC. For Gofman's account of these
conflicts, see "The Controversy Over Nuclear-Armed Antiballistic Missiles
(1969)" in the Gofman transcript. A contrasting view is presented by the
AEC's John Totter in his transcript (DOE/EH-0481, September 1995).
(22)U.S. physicist, 190158; a pioneer in nuclear
physics who built and operated (with M. Stanley Livingston and Milton White) the
first cyclotron in 1930 on the Berkeley campus of the University of California;
established the University of California Radiation Laboratory in 1936 and served
as its director until his death.
(23)Hardin B. Jones, M.D., studied isotope
applications in nuclear medicine and showed uptake of iodine-131 by human and
bovine thyroids. He was a member of the National Advisory Committee on Radiation
of the Federal Radiation Council. Politically conservative, Jones took a stand
against the counter-culture movement at Berkeley during the '60s. He died of a
heart attack in the late '70s. See "Reflections on Hardin Jones" in
DOE/EH-0476, Human Radiation Studies: Remembering the Early Years; Oral
History of Physiologist Nello Pace, Ph.D. (June 1995).
(24)Tobias was a professor of medical physics and
radiology at the Donner Laboratory and the University of California at Berkeley.
Dr. Tobias's main research focused on the biological effects of radiation;
cancer research; and space medicine. For the transcript of the interview with
Tobias, see DOE/EH-0480, Human Radiation Studies: Remembering the Early
Years; Oral History of Biophysicist Cornelius A. Tobias, Ph.D. (July
1995).
(25)diagnostic and therapeutic medical techniques
using radionuclides or radioisotopes
(26)the branch of biology that applies the methods of
physics to the study of biological structures and processes
(27)a hematologist who conducted biophysics research at the
UC Radiation Laboratory; as of this publication, Dr. Pollycove was serving as a
consultant to the Nuclear Regulatory Commission, in Rockville, Maryland.
(28)University of California at San Francisco
(29)an accelerator in which protons are raised to very
high energy levels, measured in billion electron-volts (BeV), by modulating the
frequency of accelerating voltage. Derives its name from BeV + a (connective) +
tron.
(30)a disorder of the pituitary gland in which too much
growth hormone is produced, resulting in enlargement of the head, hands, and
feet
(31)a disorder of metabolism caused by overproduction of
the hormone ACTH in the pituitary gland, resulting in hypertension, striated
skin, accumulations of fat on the face and other areas, and various other
disturbances
(32)by irradiating only the pituitary gland, believing
that breast cancer was a hormonally driven disease
(33)a biologist who studies the functions and activities of
living organisms and their parts
(34)Ernest L. Dobson, Ph.D., was a biophysicist who
was born in Beijing, China, in 1914 and became a U.S. citizen. He worked as a
physiologist at the Lawrence Radiation Laboratory from 1946 until his death,
conducting research on the physiology of the circulatory system.
(35)Lola Szanto Kelly, Ph.D., a biologist born in
Vienna, Austria who became a naturalized U.S. citizen. Dr. Kelly worked at the
Donner Laboratory under Hardin Jones. She worked with Ernest Dobson on
phosphorus-32 colloids in the liver and conducted research on nucleic acid
metabolism and the biological effects of radiation.
(36)From 1951 to 1977, Durbin worked as a chemist and
radiobiologist at Crocker Laboratory. For the transcript of the November, 11,
1994 interview with Durbin, see DOE/EH-0458, Human Radiation Studies:
Remembering the Early Years; Oral History of Dr. Patricia Wallace Durbin, Ph.D.
(June 1995).
(37)Whaley is apologizing for the armchair psychology
that is to follow.
(38)Ernest Lawrence's ingenuity and drive made the
Berkeley-based Radiation Laboratory a center of nuclear physics in the United
States.
(39)polycythemia vera, a disease characterized
by overproduction of red blood cells
(40)an endocrine gland located at the base of the neck and
secreting two hormones that regulate the rates of metabolism, growth, and
development
(41)relating to the nature, function, and diseases
of the blood and of blood-forming organs
(42)Dr. Alexander Hollaender became the director of the
Biology Division at Oak Ridge National Laboratory.
(43)During World War II, the Manhattan Project had
built a vast complex of highly classified facilities in and near Oak Ridge,
Tennessee, to process and enrich uranium for use in atomic bombs. The Atomic
Energy Commission assumed control of these facilities upon its creation and,
today, they belong to the Department of Energy.
(44)U.S. chemist, born 1912, professor of Chemistry at
the University of California, Berkeley, discoverer of several heavy elements,
and Nobel Prize recipient in 1952. Seaborg later served as Director of the AEC.
(45)From 1941 to 1943, Gofman developed two processes
for separating plutonium from the uranium and fission products of irradiated
fuel. This work, conducted with Dr. Glenn Seaborg, was the precursor to
full-scale plutonium production at the Hanford Nuclear Site in Washington.
(46)At the UC San Francisco Medical School, the
Gold-Headed Cane was given to the senior medical student with the best promise
of being, in Gofman's words, a "true physician."
(47)any of the class of proteins that combine a lipid
with a simple protein
(48)In 1948, a paper published by Gofman et al. opened the
way for the discovery of the sequence of low-density lipoproteins. For his work
on heart disease, Gofman received the Stouffer Prize in 1972 and in 1994 was a
guest speaker at the American Heart Association. See "Heparin and
Lipoprotein Research With Human Subjects" in the Gofman transcript.
(49)the use of a centrifuge that rotates at a very high
speed and separates and sediments the molecules of a substance
(50)See the footnote on the new Livermore division, on
page 3.
(51)radioactive debris from a nuclear detonation
or other source. Fallout is usually deposited from airborne particles.
(52)For more discussion of the genesis of the Lawrence
Livermore fallout studies program, see "Livermore Biomedical Division;
Conflicts with John Gofman (196272)" in the John Totter transcript
(DOE/EH-0481, September 1995).
(53)use of an electron microscope, a microscope of
extremely high power that uses beams of electrons focused by magnetic lenses
instead of rays of light; the magnified image is formed on a fluorescent screen
or recorded on a photographic plate.
(54)Lawrence Berkeley Laboratory Hill refers to the
hillside, overlooking Berkeley and San Francisco Bay, where the Lab is situated.
(55)the small gland attached to the base of the brain,
constituting the master endocrine gland affecting all hormonal functions of the
body
(56)double coneconically distributed radiation dose to
tissues between the beam source and the pituitary, one on each side of the
patient's head
(57)a hybrid of two accelerators: a bevatron and a
super-HILAC or Heavy Ion Linear ACcelerator
(58)pertaining to or affecting an artery and a vein
(59)conditions characterized by an imbalance of the
constituents of the blood
(60)See "Conflict Between University of California San
Francisco and Berkeley" in the Gofman transcript.
(61)A pioneer in radiation therapy, Robert Stone, M.D., had
conducted human radiation studies before World War II. He was an early
researcher at the Lawrence Radiation Laboratory and became a major figure in
radiobiology research. When Joseph Hamilton began operating his 60-inch
cyclotron at Crocker Laboratory, Stone requested that fission products be made
on the cyclotron and that their fate in mammals be systematically studied in
small animals. That information would be used for radiation protection proposes.
In 1942, while chairing the Department of Radiology at UC San Francisco's
medical school, Stone was recruited to lead the Medical Division of the
Manhattan Project, overseeing all biological, medical, and radiological
protection research. Accordingly, he moved to the University of Chicago, where
he served as Associate Director for Health under Arthur Compton. In the 1950s,
after serving in the Atomic Energy Commission, Stone returned to his post at the
UCSF as head of the Department of Radiology. Under Stone, UCSF acquired a 70-MeV
synchrotron for conducting therapeutic research.
(62)a medical researcher at the University of California,
San Francisco who died prematurely of leukemia, probably brought on by
overexposure to radiation in the course of his career, which included work with
radiophosphorus in England. Low-Beer, a physician, had been trained in his
native Czechoslovakia. He served as an associate professor of Radiation Therapy
before heading the Radiation Therapy Division of the Department of Radiology at
UC San Francisco.
(63)Massachusetts Institute of Technology, Cambridge,
Massachusetts
(64)A neurosurgeon now practicing nuclear medicine at
Harvard. As a medical student at Harvard, Kjellberg trained under Cornelius
Tobias, who was serving as a visiting professor.
(65)inside the body
(66)devices that measure radioactivity by registering the
number of scintillations (ionizations of a phosphor struck by a photon or
energetic particle) it produces
(67)the process of producing a PET scan, a medical image
obtained by examination with a PET scanner, a device that produces computerized
three-dimensional images of biochemical activity in the brain or other organ
through use of radioactive tracers that emit positrons and twin 0.511-MeV gamma
rays
(68)Mr. Whaley added later: "As long as I have known
him and even though he's gone, I can't call him John; I absolutely cannot do
that."
(69)the U.S. Government's secret project, launched December
28, 1942 by the U.S. Army Corps of Engineers' Manhattan Engineer District, to
develop the atomic bomb. Headquarterd in Washington, D.C., the Manhattan project
was the Office of Scientific Research and Developement Section on Uranium and
was codenamed S-1 (Section One of the Office of Scientific Research
Developement)
(70)science whose research activities typically require
large, costly facilities and hundreds of individuals
(71)a broad-scale program sponsored by the National
Institutes of Health and the Department of Energy to map the location of every
gene of all 47 human chromosomes
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