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Oral Histories

Donner Lab Administrator Baird G. Whaley


Foreword

Short Biography

Hiring On at the Donner Laboratory

Non–AEC-Funded Projects; the "Odd Funds"

Creation of the Donner Laboratory

Reflections on John Lawrence as Laboratory Director

John Gofman: Research and Controversy

Cornelius Tobias

Budgeting and Staffing

Patient Care in the Donner Clinic Research Program

Changes in Laboratory Organization Under Ed Alpen

The Donner Pavilion

Changes in Research Funding

(1)UC Radiation Laboratory; renamed Lawrence Radiation Laboratory; now Lawrence Berkeley Laboratory, a national laboratory of the U.S. Department of Energy; founded by Ernest Lawrence in 1936

(2)a laboratory set up at the UC Radiation Laboratory in Berkeley during the 1930s specifically to conduct experiments in medical physics

(3)Dr. John Lawrence, brother of Ernest O. Lawrence, was Director of the Division of Medical Physics at the University of California, Berkeley. He operated a clinic at Donner Laboratory, where he treated leukemia and polycythemia vera patients with radioactive phosphorus.

(4)Mr. Whaley added later: "We used to joke a bit that one of Dr. Lawrence's principal ways of concluding an interview was to hire people. He had a little difficulty sometimes in saying 'no'."

(5)Mr. Whaley added later: "He was the director until 1970, and then went on the Regents."

(6)the U.S. Atomic Energy Commission, predecessor agency to the U.S. Department of Energy and Nuclear Regulatory Commission (NRC); established January 1, 1947

(7)Lawrence Livermore National Laboratory, Livermore, California

(8)John Gofman was a physician and biophysicist. For the interview with Gofman, see DOE/EH-0457, Human Radiation Studies: Remembering the Early Years; Oral History of Dr. John W. Gofman, M.D. (June 1995).

(9)The Biomedical Division at Lawrence Livermore was set up in 1962 by the chairman of AEC's Division of Biology and Medicine, Charles Dunham. The establishment of this laboratory is discussed under "Livermore Biomedical Division; Conflicts With John Gofman (1962–72)" in the John R. Totter transcript (DOE/EH-0481, September 1995). For insight into discussions leading to establishing this laboratory from Dr. Gofman's perspective, see "Establishing Livermore Laboratory's Division of Biology and Medicine" and "Jack, all we want is the truth" in the Gofman transcript (DOE/EH-0457, June 1995).

(10)Lawrence belonged to the Bohemian Club, an exclusive social club in the San Francisco area known for back-to-nature retreats at the Bohemian Grove (North of San Francisco, in the Russian River country) and the power and influence of its members.

(11)a firm that develops and manufactures drugs approved for human use

(12)Lilly has not merged with or been acquired by another firm.

(13)Merck & Co., Inc., based in White House Station, New Jersey, remains one of the largest pharmaceutical firms in the United States.

(14)Mr. Whaley added later: "I went back and helped with a lawsuit in 1990. And using my recollection of things that had gone on in the late seventies and early eighties, I was surprised at the number of things that I had forgotten or I hadn't remembered quite correctly."

(15)The U.S. Energy Research and Development Administration succeeded the AEC in the early '70s, and in turn was replaced by the DOE in 1977.

(16)U.S. Department of Energy, created in 1977

(17)Mr. Whaley added later: "When I speak of 'our office,' that included Jim Born, who was the assistant director. He was also heavily involved in the medical research end of it; and Janice DeMoor was a physiologist. [Though she moved away shortly after I joined the Lab,] she is certainly somebody you should talk to, and was there longer than I was. I think she's still alive and functioning and lives here in Berkeley."

(18)an accelerator in which particles move in spiral paths in a constant magnetic field

(19)Joseph Hamilton, an M.D., worked at Crocker Laboratory, then the site of a 60-inch cyclotron that he operated to produce radioisotopes in support of research and some medical diagnosis and treatment. Crocker was part of the Lawrence Radiation Laboratory.

(20)The rivalry between Crocker and Donner, two branches of the Lawrence Radiation Laboratory, is discussed by Gofman in the transcript of his interview (DOE/EH-0457).

(21)Gofman's public views and outspoken style brought him into frequent conflict with the AEC. For Gofman's account of these conflicts, see "The Controversy Over Nuclear-Armed Antiballistic Missiles (1969)" in the Gofman transcript. A contrasting view is presented by the AEC's John Totter in his transcript (DOE/EH-0481, September 1995).

(22)U.S. physicist, 1901–58; a pioneer in nuclear physics who built and operated (with M. Stanley Livingston and Milton White) the first cyclotron in 1930 on the Berkeley campus of the University of California; established the University of California Radiation Laboratory in 1936 and served as its director until his death.

(23)Hardin B. Jones, M.D., studied isotope applications in nuclear medicine and showed uptake of iodine-131 by human and bovine thyroids. He was a member of the National Advisory Committee on Radiation of the Federal Radiation Council. Politically conservative, Jones took a stand against the counter-culture movement at Berkeley during the '60s. He died of a heart attack in the late '70s. See "Reflections on Hardin Jones" in DOE/EH-0476, Human Radiation Studies: Remembering the Early Years; Oral History of Physiologist Nello Pace, Ph.D. (June 1995).

(24)Tobias was a professor of medical physics and radiology at the Donner Laboratory and the University of California at Berkeley. Dr. Tobias's main research focused on the biological effects of radiation; cancer research; and space medicine. For the transcript of the interview with Tobias, see DOE/EH-0480, Human Radiation Studies: Remembering the Early Years; Oral History of Biophysicist Cornelius A. Tobias, Ph.D. (July 1995).

(25)diagnostic and therapeutic medical techniques using radionuclides or radioisotopes

(26)the branch of biology that applies the methods of physics to the study of biological structures and processes

(27)a hematologist who conducted biophysics research at the UC Radiation Laboratory; as of this publication, Dr. Pollycove was serving as a consultant to the Nuclear Regulatory Commission, in Rockville, Maryland.

(28)University of California at San Francisco

(29)an accelerator in which protons are raised to very high energy levels, measured in billion electron-volts (BeV), by modulating the frequency of accelerating voltage. Derives its name from BeV + a (connective) + tron.

(30)a disorder of the pituitary gland in which too much growth hormone is produced, resulting in enlargement of the head, hands, and feet

(31)a disorder of metabolism caused by overproduction of the hormone ACTH in the pituitary gland, resulting in hypertension, striated skin, accumulations of fat on the face and other areas, and various other disturbances

(32)by irradiating only the pituitary gland, believing that breast cancer was a hormonally driven disease

(33)a biologist who studies the functions and activities of living organisms and their parts

(34)Ernest L. Dobson, Ph.D., was a biophysicist who was born in Beijing, China, in 1914 and became a U.S. citizen. He worked as a physiologist at the Lawrence Radiation Laboratory from 1946 until his death, conducting research on the physiology of the circulatory system.

(35)Lola Szanto Kelly, Ph.D., a biologist born in Vienna, Austria who became a naturalized U.S. citizen. Dr. Kelly worked at the Donner Laboratory under Hardin Jones. She worked with Ernest Dobson on phosphorus-32 colloids in the liver and conducted research on nucleic acid metabolism and the biological effects of radiation.

(36)From 1951 to 1977, Durbin worked as a chemist and radiobiologist at Crocker Laboratory. For the transcript of the November, 11, 1994 interview with Durbin, see DOE/EH-0458, Human Radiation Studies: Remembering the Early Years; Oral History of Dr. Patricia Wallace Durbin, Ph.D. (June 1995).

(37)Whaley is apologizing for the armchair psychology that is to follow.

(38)Ernest Lawrence's ingenuity and drive made the Berkeley-based Radiation Laboratory a center of nuclear physics in the United States.

(39)polycythemia vera, a disease characterized by overproduction of red blood cells

(40)an endocrine gland located at the base of the neck and secreting two hormones that regulate the rates of metabolism, growth, and development

(41)relating to the nature, function, and diseases of the blood and of blood-forming organs

(42)Dr. Alexander Hollaender became the director of the Biology Division at Oak Ridge National Laboratory.

(43)During World War II, the Manhattan Project had built a vast complex of highly classified facilities in and near Oak Ridge, Tennessee, to process and enrich uranium for use in atomic bombs. The Atomic Energy Commission assumed control of these facilities upon its creation and, today, they belong to the Department of Energy.

(44)U.S. chemist, born 1912, professor of Chemistry at the University of California, Berkeley, discoverer of several heavy elements, and Nobel Prize recipient in 1952. Seaborg later served as Director of the AEC.

(45)From 1941 to 1943, Gofman developed two processes for separating plutonium from the uranium and fission products of irradiated fuel. This work, conducted with Dr. Glenn Seaborg, was the precursor to full-scale plutonium production at the Hanford Nuclear Site in Washington.

(46)At the UC San Francisco Medical School, the Gold-Headed Cane was given to the senior medical student with the best promise of being, in Gofman's words, a "true physician."

(47)any of the class of proteins that combine a lipid with a simple protein

(48)In 1948, a paper published by Gofman et al. opened the way for the discovery of the sequence of low-density lipoproteins. For his work on heart disease, Gofman received the Stouffer Prize in 1972 and in 1994 was a guest speaker at the American Heart Association. See "Heparin and Lipoprotein Research With Human Subjects" in the Gofman transcript.

(49)the use of a centrifuge that rotates at a very high speed and separates and sediments the molecules of a substance

(50)See the footnote on the new Livermore division, on page 3.

(51)radioactive debris from a nuclear detonation or other source. Fallout is usually deposited from airborne particles.

(52)For more discussion of the genesis of the Lawrence Livermore fallout studies program, see "Livermore Biomedical Division; Conflicts with John Gofman (1962–72)" in the John Totter transcript (DOE/EH-0481, September 1995).

(53)use of an electron microscope, a microscope of extremely high power that uses beams of electrons focused by magnetic lenses instead of rays of light; the magnified image is formed on a fluorescent screen or recorded on a photographic plate.

(54)Lawrence Berkeley Laboratory Hill refers to the hillside, overlooking Berkeley and San Francisco Bay, where the Lab is situated.

(55)the small gland attached to the base of the brain, constituting the master endocrine gland affecting all hormonal functions of the body

(56)double cone—conically distributed radiation dose to tissues between the beam source and the pituitary, one on each side of the patient's head

(57)a hybrid of two accelerators: a bevatron and a super-HILAC or Heavy Ion Linear ACcelerator

(58)pertaining to or affecting an artery and a vein

(59)conditions characterized by an imbalance of the constituents of the blood

(60)See "Conflict Between University of California San Francisco and Berkeley" in the Gofman transcript.

(61)A pioneer in radiation therapy, Robert Stone, M.D., had conducted human radiation studies before World War II. He was an early researcher at the Lawrence Radiation Laboratory and became a major figure in radiobiology research. When Joseph Hamilton began operating his 60-inch cyclotron at Crocker Laboratory, Stone requested that fission products be made on the cyclotron and that their fate in mammals be systematically studied in small animals. That information would be used for radiation protection proposes. In 1942, while chairing the Department of Radiology at UC San Francisco's medical school, Stone was recruited to lead the Medical Division of the Manhattan Project, overseeing all biological, medical, and radiological protection research. Accordingly, he moved to the University of Chicago, where he served as Associate Director for Health under Arthur Compton. In the 1950s, after serving in the Atomic Energy Commission, Stone returned to his post at the UCSF as head of the Department of Radiology. Under Stone, UCSF acquired a 70-MeV synchrotron for conducting therapeutic research.

(62)a medical researcher at the University of California, San Francisco who died prematurely of leukemia, probably brought on by overexposure to radiation in the course of his career, which included work with radiophosphorus in England. Low-Beer, a physician, had been trained in his native Czechoslovakia. He served as an associate professor of Radiation Therapy before heading the Radiation Therapy Division of the Department of Radiology at UC San Francisco.

(63)Massachusetts Institute of Technology, Cambridge, Massachusetts

(64)A neurosurgeon now practicing nuclear medicine at Harvard. As a medical student at Harvard, Kjellberg trained under Cornelius Tobias, who was serving as a visiting professor.

(65)inside the body

(66)devices that measure radioactivity by registering the number of scintillations (ionizations of a phosphor struck by a photon or energetic particle) it produces

(67)the process of producing a PET scan, a medical image obtained by examination with a PET scanner, a device that produces computerized three-dimensional images of biochemical activity in the brain or other organ through use of radioactive tracers that emit positrons and twin 0.511-MeV gamma rays

(68)Mr. Whaley added later: "As long as I have known him and even though he's gone, I can't call him John; I absolutely cannot do that."

(69)the U.S. Government's secret project, launched December 28, 1942 by the U.S. Army Corps of Engineers' Manhattan Engineer District, to develop the atomic bomb. Headquarterd in Washington, D.C., the Manhattan project was the Office of Scientific Research and Developement Section on Uranium and was codenamed S-1 (Section One of the Office of Scientific Research Developement)

(70)science whose research activities typically require large, costly facilities and hundreds of individuals

(71)a broad-scale program sponsored by the National Institutes of Health and the Department of Energy to map the location of every gene of all 47 human chromosomes