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Oral Histories

Physiologist Nello Pace, Ph.D.


Foreword

Short Biography

Education at UC Berkeley (1932–40) and Medical College of Virginia (1940–41); Service in Naval Reserves

Tritium Injection Experiments in Animals and Humans During WW II

Hospitality to Manhattan Project Researchers Staying in Washington

Return to UC Berkeley to Research and Teach

Development of Medical Physics Degree Programs at UC Berkeley

Conducting the First Radiation Survey at Nagasaki After the Bomb

Censured by the Military for Underclassifying His Nagasaki Report

Reflections on Shields Warren

The Public's Attitudes Toward Radiation, Then and Now

Establishment of a Research Lab at White Mountain (1950)

Use of the White Mountain Research Station

Research in the Organic Distribution Rate of Carbon Monoxide

Research in Physiological Responses to Thermal Extremes and Burns

How He Procured Isotopes for His Research

Willingness of Students and Naval Reservists to Volunteer for Radiation Experiments; Informed Consent

Inert Gas Research for Treating the Bends in Divers

How Naval Research Projects Were Decided Upon

Reflections on Hardin Jones

Reflections on John Lawrence

Reflections on Joe Hamilton

Differences Between Berkeley's Medical Physics and Biophysics Program

Donner Researchers Who Went On to Serve in Area Hospitals

Radioisotopes He Used in Research

Recollections on John Gofman

1an accelerator in which particles move in spiral paths in a constant magnetic field

2a isotope of hydrogen, having twice the mass of ordinary hydrogen (protium); "heavy hydrogen"

3incorporated with a radioactive isotope to make a substance traceable

4a small amount of radioactive materials used in place of stable forms of the same element to track a biological or chemical process

5the Manhattan Project—the U.S. Government's ultrasecret project to develop an atomic bomb

6an abnormality of the eye in which the lens becomes partially or completely opaque

7U.S. chemist, born 1912; discovered plutonium in 1940 and played a key role in the discovery of more than half a dozen new elements through the 1950s

8the U.S. Army Corps of Engineers organization set up to administer the development of the atomic bomb under the ultrasecret Manhattan Project. Originally headquartered in New York, it was moved to Washington, DC, and finally to Oak Ridge, Tennessee, in the summer of 1943. In 1947 it became the Atomic Energy Commission.

9For the transcript of the interview with Tobias, see DOE/EH-0480, Human Radiation Studies: Remembering the Early Years; Oral History of Biophysicist Cornelius A. Tobias, Ph.D. (July 1995).

10The U.S. Army Air Corps became the U.S. Air Force, a separate military service, on September 18, 1947.

11The bends are caused by tiny air bubbles released into tissue by a too-rapid decrease in air pressure after staying in a compressed atmosphere, such as the too-rapid ascent of a diver from deep in the sea to normal atmosphere at sea level. It is potentially fatal. Aviators experience a similar phenomenon in ascending too rapidly to high altitude in an unpressurized cockpit without the protection of a pressurized flightsuit. In this circumstance, aviators are at high risk of blacking out and losing control of their aircraft.

12Director of the Division of Medical Physics at the University of California, Berkeley. He operated a clinic at Donner Laboratory, where he treated leukemia and polycythemia vera patients with radioactive phosphorus. For a colleague's recollection of Dr. Lawrence's clinic, see in the interview with Dr. John Gofman (DOE/EH-0457, June 1995), the sections "From Research to Laboratory Production of Plutonium," "Medical Treatments With Radioactive Phosphorus (32P)," "Conflict Between University of California San Francisco and Berkeley," "Heparin and Lipoprotein Research With Human Subjects," and "Radiophosphorus Therapy for Polycythemia Vera."

13a laboratory set up at the UC Radiation Laboratory in Berkeley during the 1930s specifically to conduct experiments in medical physics

14an exclusive social club in the San Francisco area, known for back-to-nature retreats to Bohemian Grove (north of San Francisco, in the Russian River country) and the power and influence of its members

15now Lawrence Berkeley Laboratory, a National Laboratory under the U.S. Department of Energy; originally founded by Ernest Lawrence as the UC Radiation Laboratory in 1936

16an instrument for detecting ionizing radiation, used chiefly to measure radioactivity

17the atomic bombs dropped by U.S. bombers over Hiroshima and Nagasaki, Japan, on August 6 and August 9, 1945, respectively

18Both General Douglas MacArthur, who was Commander-in-Chief Southwestern Pacific, and Admiral Chester Nimitz, CINCPAC, had been informed by the War Department of the existence and impending use of the atomic bomb in late July 1945. See William Manchester, American Caesar, Boston: Little, Brown and Co. (1978), p. 438. MacArthur was greatly angered on being informed that General Eisenhower and several other commanders had learned of the atomic bomb much earlier than he. See Michael Shaller, Douglas MacArthur, the Far Eastern General, New York: Oxford University Press (1989), p.117.

19a commercial airliner; the military transport variant was known as the C-47.

20General Leslie R. Groves, U.S. Army, took command of the Manhattan Engineer District in 1942 and led it to completion of the Manhattan Project.

21the University of Rochester, Rochester, New York, site of research involving plutonium and human subjects

22plural of half-life, the time required for half the atoms of a radioactive substance to decay

23University of California at Los Angeles

24diagnostic and therapeutic medical techniques using radionuclides or radioisotopes

25For an extended review of the use of radioiodine to treat thyroid disorders, see see DOE/EH-0465, Human Radiation Studies: Remembering the Early Years; Oral History of Dr. Nadine Foreman, M.D. (July 1995).

26a mountain in eastern California, in the Sierra Nevada; 14,495 feet (4,418 meters)

27Berge later interviewed Siri for this publication series, but the resulting transcript was unusable as it is full of lacunae.

28tracked, all-terrain vehicles with covered cabs for use in arctic areas

29Lawrence Livermore National Laboratory, Livermore, California

30the Andes mountain range in the western part of South America

31Carbon-12 is the ubiquitous stable isotope; Pace probably meant carbon-11, which has a half-life of 20.4 minutes.

32a condition of pallor, very low blood pressure, feeble rapid pulse, decreased respiration, restlessness, anxiety, and sometimes unconsciousness that may be experienced by someone who has just been severely or extensively burned

33the U.S. Marine Corps' Cold Weather Training Facility in northern California, near Bridgeport

34During World War II, the Manhattan Project had built a vast complex of highly classified facilities in and near Oak Ridge, Tennessee, to process uranium for use in atomic bombs. The Atomic Energy Commission took control of these facilities upon its creation and, today, they belong to the Department of Energy.

35Hoover Institution on War, Revolution, and Peace, founded in 1919 by Herbert Hoover and located at Stanford University, Stanford, California. Hoover researchers conduct interdisciplinary research in the social sciences and public policy.

36For the transcript of the interview with Durbin, see DOE/EH-0458, Human Radiation Studies: Remembering the Early Years; Oral History of Dr. Patricia Wallace Durbin, Ph.D. (June 1995).

37University of California at San Francisco

38For the transcript of the interview with Gofman, see DOE/EH-0457, Human Radiation Studies: Remembering the Early Years; Oral History of Dr. John W. Gofman, M.D. (June 1995).

39Gofman addresses the background radiation in his interview, under the section, "Concern Over Low-Dosage Harm; Public Acceptance of Nuclear Energy."