(1)an endocrine gland
located at the base of the neck and secreting two hormones that regulate the
rates of metabolism, growth, and development
(2)overactivity of the
thyroid gland, resulting in increased metabolism rate
(3)For the transcript of
the interview with Miller, see DOE/EH-0474, Human Radiation Studies:
Remembering the Early Years; Oral History of Radiologist Earl R. Miller, M.D.
(July 1995).
(4)an enlargement of the
thyroid gland on the front and sides of the neck
(5)The thyroid would be
weighed after being surgically removed.
(6)a radioactive tag on
biomolecules, used to study biological or chemical systems
(7)a measure of
radioactivity equal to one millionth of a curie
(8)two atoms of iodine
forming a molecule
(9)a temporary or permanent
decrease or subsidence of the manifestations of the disease
(10)assimilate
(11)of or pertaining to
pathology, the science or the study of the origin, nature, and course of
diseases
(12)a small, rounded mass
or lump
(13)use of photographic
film placed over thinly sliced tissue to record, in image form, the radiation
tracks from the tissue that pass through the film's emulsion
(14)characterized by
nodules (small, rounded masses or lumps)
(15)highly penetrating
photons of high frequency, usually 1019 Hz or more, emitted by atomic nuclei
(16)release of electrons
or positrons during radioactive decay
(17)a measure of
radioactivity equal to one thousandth of a curie or one thousand microcuries
(18)"Right off the
reel" means from the start/beginning.
(19)counted the rate of
radiation emissions, using radiation detection instruments
(20)pertaining to the
liver
(21)characterized by an
abnormal multiplication of cells
(22)an instrument for
detecting ionizing radiation and measuring dose rate
(23)analog counters, for
counting the number of pulses in the detector
(24)a laboratory set up at
the UC Radiation Laboratory in Berkeley during the 1930s specifically to conduct
experiments in medical physics
(25)a slender graduated
tube for measuring liquids or transferring them from one container to another
(26)20 cubic centimeters
(about 0.7 fluid ounce)
(27)a graduated glass tube
with a stopcock at the bottom, used in a laboratory to measure or dispense
liquids
(28)to determine the rate
at which the goiter was shrinking
(29)urine samples taken
24 hours after radioiodine had been administered
(30)the U.S. Atomic Energy
Commission, predecessor agency to the U.S. Department of Energy and Nuclear
Regulatory Commission (NRC); established January 1, 1947
(31)For the transcript of
the interview with Gofman, see DOE/EH-0457, Human Radiation Studies:
Remembering the Early Years; Oral History of Dr. John W. Gofman, M.D. (June
1995).
(32)a peer of Joseph
Hamilton's at Crocker Laboratory. Scott severed his ties with Crocker in the
early '50s, moving his operations to San Francisco, where he took a tenured
position, setting up and running UCSF's radioisotopes laboratory. (Source:
Durbin interview, DOE/EH-0458)
(33)tumors: uncontrolled,
abnormal, circumscribed growths of cells in any tissue; neoplasms
(34)the branch of science
dealing with the components of the immune system, immunity from disease, the
immune response, and immunologic techniques of analysis
(35)an excess assimilation
of radioiodine in the thyroid, indicating abnormality
(36)a medical specialist
who studies the nature, function, and diseases of the blood and of blood-forming
organs
(37)Dr. John Lawrence,
brother of Ernest O. Lawrence, was Director of the Division of Medical Physics
at University of California, Berkeley. He operated a clinic at Donner
Laboratory, where he treated leukemia and polycythemia patients with radioactive
phosphorus. For a colleague's recollection of Dr. Lawrence's clinic, see the
interview with Dr. John Gofman (DOE/EH-0457), the sections "From Research
to Laboratory Production of Plutonium," "Medical Treatments With
Radioactive Phosphorus (32P)," "Conflict Between University of
California San Francisco and Berkeley," "Heparin and Lipoprotein
Research With Human Subjects," and "Radiophosphorus Therapy for
Polycythemia Vera."
(38)polycythemia vera, a
disease characterized by overproduction of red blood cells
(39)the practice or
profession of examining the eyes for defects of vision and eye disorders in
order to prescribe corrective lenses or other appropriate treatment
(40)Radioiodine (131I) is
still a highly effective therapy for hyperthroidism, Graves' disease, and
thyroid cancer.
(41)The depletion results
in thickening of the skin, blunting of the senses and intellect, and labored
speech and, in children, cretinism (stunted growth, deformity, and mental
retardation).
(42)deficiency in thyroid
secretions
(43)A pioneer in radiation
therapy, Robert Stone, M.D., had conducted human radiation studies before World
War II. He was an early researcher at the Lawrence Radiation Laboratory and
became a major figure in radiobiology research. When Joseph Hamilton began
operating his 60-inch cyclotron at Crocker Laboratory, Stone requested that
fission products be made on the cyclotron and that their fate in mammals be
systematically studied in small animals. That information would be used for
radiation protection proposes. In 1942, while chairing the Department of
Radiology at UC San Francisco's medical school, Stone was recruited to lead the
Medical Division of the Manhattan Project, overseeing all biological, medical,
and radiological protection research. Accordingly, he moved to the University of
Chicago, where he served as Associate Director for Health under Arthur Compton.
In the 1950s, after serving in the Atomic Energy Commission, Stone returned to
his post at the UCSF as head of the Department of Radiology. Under Stone, UCSF
acquired a 70-MeV synchrotron for conducting therapeutic research.
(44)a researcher at the
University of California, San Francisco who died prematurely of leukemia,
probably brought on by overexposure to radiation in the course of his career,
which included work with radiophosphorus in England. Low-Beer, a physician, had
been trained in his native Czechoslovakia. He served as an associate professor
of Radiation Therapy before heading the Radiation Therapy Division of the
Department of Radiology at UC San Francisco.
(45)the soft, fatty
vascular tissue in the cavities of bones; it is a major site of blood-cell
production.
(46)a disease
characterized by an enlarged thyroid, rapid pulse, and increased basal
metabolism due to excessive thyroid secretion
(47)The UC Radiation
Laboratory was founded by Ernest Lawrence in 1936 on the campus of University of
California at Berkeley. Upon Lawrence's death, the lab's name was changed to
Lawrence Radiation Laboratory. The name changed again, in 1971, to Lawrence
Berkeley Laboratory, a National Laboratory under the U.S. Department of Energy.
(48)For
the transcript of the interview with Friedell, see DOE/EH-0466, Human
Radiation Studies: Remembering the Early Years; Oral History of Radiologist
Hymer L. Friedell, Ph.D. (July 1995).
|