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Record Series Descriptions
Roadmap to the Project
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Records Series Descriptions
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Oak Ridge Institute for Science and Education (ORISE) 
  SERIES TITLE      DOE/ORISE DTPA Program and Registry 
  INCLUSIVE DATES   1959 present 
  ARRANGEMENT  Record type 
  VOLUME  12 cubic feet 
  DESCRIPTION  The series consists of correspondence, reports, 
               publications, and patient registries  (electronic 
               as well as hard copy) relating to efforts to 
               reduce transuranic body burdens  through chemical 
               chelation. These burdens typically were acquired 
               by nuclear workers who had inhaled or ingested 
               materials such as plutonium. Chelation is a 
               process  that attempts to speed excretion of 
               materials such as plutonium and other  
               transuranics through administration of chemical 
               compounds. DTPA is approved by  FDA as an 
               Investigational New Drug (IND) for chelation of 
               selected transuranic elements such as plutonium. 
               Subjects covered include human use protocols, 
               informed  consent, and patient response, as well 
               as general administration of the program. Also  
               included are historical AEC business files for the 
               DTPA program that document  activities occurring 
               prior to ORAU's involvement in 1978. 
  RESTRICTIONS  This series contains privacy material.  
  LOCATION OF RECORDS      Oak Ridge Institute for Science and 
                         Education  Medical Sciences Division   
                         150 East Road, Room A  Oak Ridge, TN 37830